Scientists at The Institute of Cancer Research (ICR) in London published new research in Nature Genetics, identifying five novel genes associated with an increased risk of developing breast cancer. The newly identified genes are MAP3K1, LZTR1, SCMH1, MYC, and ESR1. The study also found new cancer-causing mutations in previously known breast cancer genes, ATM and CHEK2.
This extensive study analyzed DNA samples from over 26,000 women diagnosed with breast cancer and 217,000 women without the disease to uncover genetic predispositions. Researchers discovered a significant overlap in genetic risk factors between breast and prostate cancer, noting 28 common genetic links, and seven shared risk factors with ovarian cancer.
Professor Clare Turnbull, who led the study at ICR, stated, 'Our study has identified new genetic changes that increase the risk of breast cancer and shed light on the mechanisms driving the disease.' These findings are expected to enhance understanding of cancer cell growth and replication, potentially guiding the development of new treatment and prevention strategies, according to Professor Kevin McGlynn of Barts Health NHS Trust and Queen Mary University of London.
